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KMID : 0380020180330040261
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Korean Journal of Biotechnology and Bioengineering
2018 Volume.33 No. 4 p.261 ~ p.267
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Effect of Ecklonia cava By-product on Immune Response and Growth Factors
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Park Keun-Tae
Park Sang-Nam
Sim In-Suk
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Abstract
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Ecklonia cava, a brown algae, is a major marine food in the Asia-Pacific region. This study analyzed the in vitro functional properties of Ecklonia cava by-product (ECBP). ECBP was prepared by drying the ethanol extraction residues of Ecklonia cava with the yield of 58% (g ECBP/g Ecklonia cava). We observed that the hot water extracts of ECBP suppressed the production of TNF-α by inhibiting its mRNA expression in RAW 264.7 cells. In contrast, gene expression of IL-6 and NF-κB increased in a dose-dependent manner. The effects of ECBP on growth factors in L6 myoblast cells showed a significant increase in insulin like growth factor-1 (IGF-1), IGF-2, and fibroblast growth factor (FGF). Therefore, we suggest that ECBP can be economic and functional feed additives for animal industry
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KEYWORD
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Ecklonia cava by product, insulin like growth factor-1, insulin like growth factor-2, fibroblast growth factor
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